Introduction

This combination medication contains two active ingredients:

• Esomeprazole 40 mg: A proton pump inhibitor (PPI) that reduces gastric acid production by blocking the final step of acid secretion in the stomach.
• Domperidone 30 mg SR (Sustained Release): A dopamine receptor antagonist that enhances gastrointestinal motility and controls nausea and vomiting. The sustained release (SR) formulation ensures a gradual release of Domperidone for a prolonged therapeutic effect.

Uses

• Treatment of acid reflux, gastroesophageal reflux disease (GERD), ulcers, and other conditions caused by excessive stomach acid.
• Management of nausea, vomiting, and delayed gastric emptying associated with Parkinson’s disease treatments.

Administration

• Take at least 1 hour before meals.
• Swallow the capsule whole without crushing or chewing.
• If swallowing is difficult, the capsule may be opened, and its contents sprinkled on one tablespoon of applesauce; swallow immediately without chewing the granules.

Storage

• Store at room temperature in a tightly closed container.
• Protect from heat, moisture, and direct light.

Mechanism of Action

• Esomeprazole inhibits the H+/K+ ATPase enzyme system in gastric parietal cells, effectively reducing gastric acid production.
• Domperidone acts as a dopamine receptor antagonist outside the blood-brain barrier, improving gastric motility and reducing nausea by enhancing esophageal sphincter pressure and promoting faster gastric emptying.

Therapeutic Class

Gastrointestinal Agent

Common Side Effects

• Dry mouth
• Headache
• Dizziness
• Abdominal cramps
• Breast pain or tenderness
• Rash, pruritus (itching)
• Diarrhea
• Somnolence (drowsiness)
• Loss of libido

Contraindications

• Avoid use during pregnancy; evidence indicates fetal risk.
• Not recommended during breastfeeding due to potential harmful effects on infants.

Safety Advice and Warnings

• Allergic Reactions: Seek immediate medical attention if symptoms such as itching, swelling (hands, face, mouth), trouble breathing or swallowing occur.
• Vitamin B12 Deficiency: Long-term use may reduce vitamin B12 absorption. Inform your doctor if you have related concerns.
• Serious Gastric Conditions: Monitor for severe gastrointestinal symptoms, especially if used alongside antibiotics.
• Hypomagnesemia: Long-term use or concurrent use with digoxin or diuretics may lead to low magnesium levels; regular monitoring may be necessary.